Possible Clues:

• 1941 Orson Welles classic
• 1941 film starring Orson Welles
• Orson Welles film
• 1941 Orson Welles film
• Movie with the line 'Old age. It's the only disease, Mr. Thompson, that you don't look forward to being cured of'
• Regarded by many as 'The best film of all time'
• AFI's top film
• The New York Inquirer was featured in it
• Film in which Agnes Moorehead debuted as the title character's mother
• Directorial triumph for 61-Across