Possible Clues:

• 'It's always something with you!'
• Kvetching exclamation
• Kvetch's words
• Yiddish 'Egad!'
• Yiddish cry of dismay
• Kvetchphrase?
• "Oh, no!"
• 'Leaving Brooklyn: ___!' (sign on the Williamsburg Bridge)
• Oral equivalent of a facepalm
• Yiddish lament