Possible Clues:

• *"... generally speaking, that's true" (In this clue's answer, note letters 5-6 and 12-14)
• Tips from Tom Hanks in leading role, mainly
• With only a few exceptions
• Team sport organised alongside river, generally
• Generally speaking
• River top, stream beaten usually
• Hatters top -- form exceptional, mainly
• At present, initiate is taking in piano chiefly
• Mainly to satisfy the doctor, begin to restrict pressure
• Proof that terms are negotiable in general