Related Clues:

• Reason to say 'alas!'
• Low spirits
• With 37-Down, popular book on grammar
• The 'vey' in 'oy vey'
• Ill
• Inner turmoil
• Sad state
• Source of despondency
• Wednesday's Child is full of it
• It's hard to bear
• Cause for weeping
• Bad tidings
• Dysphoria
• Reason to cry 'Alas!'
• Cry of grief