Possible Clues:

• Waterway with many locks
• The Seneca Chief was the first to travel its full length
• Construction project that began in Rome
• Waterway between Albany and Buffalo in New York State
• It was initially dubbed 'Clinton's Big Ditch' by its critics
• Line on New York's state quarter
• Albany-Buffalo waterway
• Waterway engineered by Clinton
• Clinton had a big role in its construction
• 1820s navigational marvel