Related Clues:

• Anguish
• Analgesic's target
• Ibuprofen target
• French bread
• Pain in the butt
• Bodily distress
• Endorphins producer
• Woe
• Hassle
• Cause of a wince
• Physical discomfort
• Major nuisance
• More than an inconvenience
• Feeling that makes you say 'Ow!'
• Great bother