Related Clues:

• __ in the neck (pest)
• Major pain
• Bothersome type
• Aleve target
• Number's target?
• Bratty kid
• Minor but aggravating problem
• Vexatious problem
• Pain in the brain
• Aspirin's target
• Reliever's target
• Pain in the behind
• Baby brother, often
• Annoyance, so to speak
• Badger or hound