Related Clues:

• Neuralgia
• Major annoyance
• Prerequisite for gain?
• No gain without it
• Problem
• Aspirin target
• Suffering partner
• Arduous chore
• Irksome sort
• Charley horse, e.g.
• Percocet's target
• What an analgesic stops
• Big pain
• It can follow a fall
• Fuss and bother