Related Clues:

• Best achievable
• Second-to-none
• Like a 63 Across?
• Most helpful
• Informal letter signoff
• At the top of the heap
• "__ in Show"
• Blue ribbon-worthy
• "Father Knows ___"
• With Banting, insulin finder
• Film-award word
• Insulin co-inventer
• Part 6 of our Christmas Carol
• Letter ender, perhaps
• Part of BFF