Related Clues:

• 'A woman with the morals of a man,' per the Urban Dictionary
• Like key lime pie
• Like grapefruit
• 'Jane, you ignorant ___' (old 'SNL' line)
• Like lemonade sans sugar
• Like sourballs
• Like crab apples
• Like lemonade
• 'Jane, you ignorant ___'
• Causing the lips to pucker
• Like unripe apples
• Sharp to the taste
• Jam-filled pastry
• Sharp in manner, biting
• The pastry sounds bitter