Related Clues:

• Embitter
• Make very angry
• Get on one's nerves
• Piss off
• Make furious
• Raise one's hackles
• Try the patience of
• Get on the bad side of
• Piss off to the nth degree
• Be a thorn in the side of
• Bother greatly
• Persistently irritate
• Bug the hell out of
• Make fume
• Make sputtering mad