Related Clues:

• Totally amazing
• Like many a villainous fictional scientist
• Throwing a hissy fit, say
• Not of sound mind
• More than a little foolish
• Certifiable?
• Boiling, in a way
• Committable?
• 5-Across relative
• Mentally out there
• Totally mad
• Really irate
• Magazine first published in 1952
• Like a wet hen?
• ___ cow disease