Possible Clues:

• Pacific divider
• You could lose a whole day going over it
• NBC show that sometimes busts sexual predators
• International boundary which, when crossed from east to west, causes a traveler to 49-Across (and a hint to this puzzle)
• NBC newsmagazine
• Article opener
• Story starter
• NBC news show
• Newspaper article header with time/place
• It includes the story's place of origin