Possible Clues:

• Conductor on the run?
• One can get off to a fast start, despite what the crossword compiler says!
• With due deference to the compiler, we want a leader here
• He's expected to step out with due regard for the dog
• Runner, first in pentathlon - top dog
• Leader of the pack
• Beginning to point, excellent hunting dog, foremost in the field
• Power shown by outstanding dog, early leader in race
• Penny and one pioneer left out to find leader
• New era shortly — PC state the end of white van man?