Possible Clues:

• City of north central Florida
• City near Silver Springs, Florida
• City whose name is derived from a Timucua Indian name
• Neighbor of Silver Springs
• Gainesville is about halfway between it and Jacksonville
• One of three national forests in Florida
• Onetime center for the distribution of oranges
• Florida Thoroughbred center
• Florida city known for thoroughbred farms
• City hidden in "local anesthetic"