Possible Clues:

• Work problem involves very big creature
• Marsupial with a grasping tail
• Surgery has problem restraining very big animal
• Work on huge problem for marsupial
• Marsupial that goes into shock when frightened
• North America's only marsupial
• One marsupial in love with another
• Creature arisen, upset after prince cracks eggs
• Post Office sent over very large amount resident of Australia carried in pouch
• American marsupial ... with or without its first letter