Possible Clues:

• First settlers of a new territory
• The first to have, by the sound of it, pie on the bottom of 5 down
• Initiates seen in repose, maybe
• Innovators
• They make advances in crossing rose with pine
• Goes first
• Avant-garde
• Some trail-blazers of Cather's creation
• Boone and Bowie
• Looks closely over one broadcast for those breaking new ground