Possible Clues:

• Question when checking on a friend ... or a hint to two pairs of letters in 17-, 30- or 43-Across
• Query of concern ... or a phonetic hint to two pairs of letters appearing in 17-, 24-, 37- and 48-Across
• “Everything all right?” and a phonetic hint to the circled letters
• "Is everything all right?"
• 'Is everything all right?'