Possible Clues:

• Opening toast with Ruth's Oriental spirit - that'll sincerely get them talking
• Set out to pen holy book, with odd barrier to fiction?
• Trust he's off alcohol -- getting treatment, to be honest
• People can't lie under it
• Substance on which it's hard to lie?
• One of those undermining creators of fiction? That'll get them talking, honestly!
• Injection in some spy movies
• Drug must hurt terribly — hesitation involved
• Opening toast with Ruth's oriental spirit - that'll sincerely get them talking
• Abusing her? Mrs Tutu means to get whoppers out