Possible Clues:

• Smelly, the French nettle bug?
• Go on irritating Republican joint
• Offensive Little Englander starts to cause irritation
• Irritate for a long time
• Irritate part of right leg
• Halfway through therapy, part of body found to keep hurting
• Cause persistent resentment to regiment on foot
• Continue to cause bitterness
• Get under one’s skin
• Cause long-lasting anger