Related Clues:

• Test the patience of
• Bug like a 24-Down
• Get on the nerves of
• Rattle one's cage
• Annoy in quirky way
• Irritate.
• Annoy, bother
• Annoy, irritate
• Annoy or irritate
• Irritate, vex
• Five hundred would make this pointed enough to bother one
• Make peeved
• Cheese off
• Really tick off
• Bug greatly