Related Clues:

• Economic and social misfortunes
• Some pollution
• Serious troubles
• Bellyaches
• Sufferings
• See 65-Across
• Contents of Pandora's box
• Babel
• Reacts to an awful pun
• Sleep disturbance
• Reformer's targets
• Plaintive sounds
• Disturber of the peace?
• Sounds of pain
• Squawks