Related Clues:

• Strongly advised
• Drove onwards when pressed
• Encouraged to shift one's ground about the East
• Pressed forward with insistence
• Soured (anag.)
• Strongly advised a bit of latitude, grudgingly turning up
• Moved manufacture of drug, having imported one?
• Woken
• Encouraged European in development of drug
• Asked, and then some
• Advocated, as caution
• Pressed four-page ad to be reduced by half
• Provided provocation
• Sounded reveille, say
• Saint framed by libertine died excited