Related Clues:

• Bent out of shape
• Nervous, with "up"
• Very upset
• Riled
• Aggravated (with up)
• Irate, with ''up''
• 'Shut your pie hole!'
• "Enough already!"
• Focused (on)
• "No more!"
• Got the goat of, with 'up'
• Much provoked
• 'Shut your trap!'
• Excited (with up)
• “Hush!”