Related Clues:

• Gets under the skin of
• Irks
• Drives up the wall
• Frosts
• Gets really ticked
• Exasperates
• Grates on
• Grinds down
• Prepares crabs, in a way
• Ruffles feathers
• Annoys over time
• Proves troublesome
• Plagues
• Aggravates
• Gets one's goat