Related Clues:

• Pain in the butt
• Bodily distress
• Endorphins producer
• Woe
• Hassle
• Cause of a wince
• Physical discomfort
• Major nuisance
• More than an inconvenience
• Feeling that makes you say 'Ow!'
• Great bother
• __ in the neck (pest)
• Major pain
• Aleve target
• Number's target?