Related Clues:

• ''.... not, want not''
• Refuse, garbage, rubbish
• Venom, harmful substance
• Spend thoughtlessly or use inefficiently
• Venom, toxin
• It causes illness or death in a living organism
• The last thing you'd take is one of this in a spoon
• One of this in a spoon might be the death of you
• The Po is on the move around the North
• Even one such in a spoon is enough to do you in
• In the spoon there's one that won't do you any good
• Not save around the middle, by the sound of it
• Here was the start of the drain
• One in the spoon, 21 down, will make one 14 down
• How the river's willing to be the death of you