Related Clues:

• Wednesday's Child is full of it
• Major apprehension
• Existential discomfort
• It's hard to bear
• Cause for weeping
• Bad tidings
• Neurotic feeling
• Reason to cry 'Alas!'
• Acute but unspecific anxiety
• See 56 Down
• Cry of grief
• Anxiety variety
• 'The Scream' evocation
• Perennial teenage feeling
• Cause of grief