Related Clues:

• Heartbreak
• Adversity
• "Alas!"
• Begone beginning
• Unfortunate condition
• The 'vey' of 'oy vey!'
• Topic of some tales
• Reason to say 'alas'
• Handwringer's feeling
• Reason to say 'alas!'
• Unhappy state
• With 37-Down, popular book on grammar
• The 'vey' in 'oy vey'
• Ill
• Inner turmoil