Related Clues:

• Wretchedness
• Sadness
• Hand-wringer's feeling
• "Ah, me!"
• Ailment
• Dejection
• Hand wringer's feeling
• Privation
• Great distress
• Blue state?
• Anguish
• Doomsayer's cry
• Ills
• Tsuris, so to speak
• Unhappiness