Related Clues:

• Distressful reaction
• "That's too hot!"
• Pained interjection
• Smart reaction
• "Yipe!" (or an apt title for this puzzle?)
• Reaction to an insect bite?
• Exclamation of sudden pain
• Exclamation of pain - that hurt!
• Yipe
• Bad-pun reaction
• Punch line?
• ''Ouch!''
• "That hurt my feelings!"
• Reaction at the gas pump
• Response to a shot, maybe