Related Clues:

• Bug big-time
• Needle, perhaps
• Sorehead's emotion
• It may need some management
• Boil one's blood
• Vex incessantly
• Cause to fret
• One might take classes to manage it
• Really annoy
• Fireplace piece
• Scratch repeatedly
• Set on edge
• Really vex
• Red state?
• Bring exasperation