Related Clues:

• "___ Get Next to You" (Temptations hit)
• Words from one who's defeated
• "It's ___!" (cry of despair)
• "Out of the question"
• "Not possible"
• Turndown from the overcommitted
• 'It's ___!' ('I give up!')
• Defeatist's phrase
• "___ Help Myself" (Four Tops hit)
• One lacks the ability to follow 1 across.6 How awkward to write up in it
• See 1 across.6 Seems that Charles the Thousandth was a deep one
• "Sorry, got plans"
• Gumption to the English is futile
• Intelligence and energy are ineffective
• Hopeless, lacking purpose