Related Clues:

• [Ask me what's wrong]
• Exhale loudly
• [I give up!]
• [Alas]
• It may accompany an eye roll
• Say 56-Across, say
• [Ugh, here we go again]
• Blimey! That girl's smuggling drugs (heroin)
• "Ah, me!" sound
• "Alas" sound
• "Ah me!" utterance
• Deep breath
• ''Alas!'' accompaniment, maybe
• Sound meaning ''That's too bad''
• Dejected sound