Related Clues:

• Ecstasy opposite
• Unending pain
• True pain
• 'Love is reciprocal ___': Marcel Proust
• Extreme suffering
• Serious suffering
• High anxiety
• ''. . . and the __ of defeat''
• Awful struggle
• Excruciating pain
• ". . . the ___ of defeat"
• 'There is no greater ___ than bearing an untold story inside you': Maya Angelou
• Song from Sondheim's 'Into the Woods'
• Extreme sorrow
• Great suffering