Related Clues:

• Endorphins producer
• Woe
• Hassle
• Cause of a wince
• Physical discomfort
• Major nuisance
• Feeling that makes you say 'Ow!'
• __ in the neck (pest)
• Aleve target
• Number's target?
• Bratty kid
• Aspirin's target
• Reliever's target
• Baby brother, often
• Annoyance, so to speak