Related Clues:

• Major annoyance
• Prerequisite for gain?
• No gain without it
• Aspirin target
• Arduous chore
• Irksome sort
• Charley horse, e.g.
• Percocet's target
• What an analgesic stops
• It can follow a fall
• Anguish
• Analgesic's target
• Ibuprofen target
• French bread
• Bodily distress