Related Clues:

• Excruciation
• Anguish
• __ center
• A long, amateurish piano recital, maybe
• Aggravation, so to speak
• Hospital's ___ center
• Woe
• Cause for contortions
• Unhappiness
• Dolor
• Heartbreak
• Ecstasy's opposite
• ''. . . the ___ of defeat''
• Shock to the system
• Word in a Charlie Brown phrase