Related Clues:

• Try the patience of
• Get on the bad side of
• Be a noodge to
• Be a thorn in the side of
• Bother greatly
• Make nuts
• Bug the hell out of
• Rile or rankle
• Be a nuisance to
• Be a pain to
• Do some button-pushing, so to speak
• Irk like crazy
• Be a pest
• Keep poking, perhaps
• Test the patience of