Related Clues:

• Really annoy
• Chafe
• Bother the heck out of
• Gnaw at
• Really ruffle
• Be a pest to
• Really bug
• Surname followed by a year in video games
• Football announcer John
• Really get to
• Make upset
• Get on one's nerves
• Piss off
• Raise one's hackles
• Be a pain in the neck