Related Clues:

• Pain in the butt
• Hassle
• Mylanta target
• Antacid target
• Anxious feeling
• More than an inconvenience
• Great bother
• Heartburn, slangily
• Major pain
• Overeater's woe
• Minor but aggravating problem
• Gut feeling
• Unsettled feeling
• Cause distress to
• Strife