Possible Clues:

• "Yes, sad to say"
• 'Regrettably, it's true'
• "Sadly, yes"
• A loud attack? Well, sadly, yes
• 'Yes, sorry to say'
• A forward's head hit Doris around top of abdomen? Sadly, that is the case!
• "I wish it weren't the case"
• “Sadly, yes”
• Scared to use a needle we hear? Sadly, that is the case!
• “Yes, sorry to say”