Possible Clues:

• With respect to the gentleman of Italy, one pays no no attention to this signore
• So it's involved with the reign, so one doesn't bother with it
• May be made to resign about nothing, but one pays no attention to that
• No, not ice. That's what one takes
• Shrugs off Italian man from start to finish
• 'One doesn't want to, no? So reign it, one does (7)'
• Is oblivious to Italian ladies first to last
• Doesn't acknowledge
• Intentionally disregards
• Passes over wild regions