Possible Clues:

• Animator, to be honest, a genius one sacked
• Plain scientist, not one that Shelley imagined
• Honest genius ditching one misguided one?
• Shelley novel
• Outspoken genius rejects one scientist playing God
• Novel conceived in 1816, the “year without a summer” after a ghost story challenge from Lord Byron
• Doctor whose shopping list might include 20-, 34- and 42-Across?
• Character whose creation is making the 10 complaints in this puzzle
• Mistaken for a monster, out­spoken scientist drops initial interest
• Destructive monster created from parts of corpses