Possible Clues:

• Rheumatic pain in the lower back
• New album by legend is over the top and a pain in the rear
• 'O, that will make a BA glum (7)'
• Mad gambol round university causes pain
• Pain — a bum log (anag)
• Business graduate in drag faces old complaint
• Complaint when graphite's not soft
• Smoker given sack for nothing but the affliction
• That'll make that stiff of a graduate leave at last
• It's a pain if pup finally slips lead!