Possible Clues:

• A source of nicotine
• Leaves stuck in pipe?
• Explorer raised company for Virginia
• What Raleigh found as explorer upset company
• It's something to chew on that it's useless in the dark
• Boot out airman caught entering Virginia, say
• For a change, Cabot & Co goes up in smoke
• Weed
• Snuff, for example
• (Treated leaves of) American plant