Possible Clues:

• Security set-up arrests a nipper somewhere in Spain
• Left for second time in state of immobility in part of Europe
• A stock of cards collected by agents in Spanish region
• The Principality of ____ included Perpignan between 1493 and 1659
• Spanish region with a strong separatist movement
• Region's irregular act, unilaterally leaving Spain, leads to immediate arrests
• Region of north-east Spain with strong separatist tradition
• Barcelona's region
• Spies protecting a Hawk's part in European region looking for independence perhaps
• A cat and a lion wandering round Spanish territory