Possible Clues:

• Comic's remark
• Sally's experienced enough to yield to pressure
• Enlightened, to take addictive drug? That's a joke!
• Funny seaweed keeping one dry
• You may ask why is cocaine a cause of mirth?
• Spoken witticism
• Learned conversation? That's a joke
• Comeback, maybe
• Joke told about end of family's split
• Pithy remark