Possible Clues:

• Ohio city west of Cleveland
• "Holy" city in Spain
• Fine blade was first to pierce further
• El Greco Museum city
• Ohio city on Lake Erie
• Uproar surrounding extremely large Spanish city
• 'Holy' city
• Spanish article raised in kerfuffle? Sword and where it's made
• With 2-Down, the oldest sister city in the U.S
• Largest Ohio city that doesn't start with "C"