Possible Clues:

• Scratchy partner on 'The Simpsons'
• Malicious bachelor exiting -- creating a nasty sensation?
• Very small, not starting to be irritating
• Switch yarns; partly a response to an allergy, perhaps?
• Like spots in which nails are often used
• Ticklish 'indrance over penultimate letter
• Like poison ivy rashes
• Affected by skin irritation
• Not satisfied
• Irritable, spiteful bishop must go